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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-4-16
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pubmed:abstractText |
Female C57Bl/6J mice were given drinking water containing 0.05% propylthiouracil to induce a hypothyroid condition. Mitochondrial glycerol-3-phosphate dehydrogenase activity, used as an index of hypothyroidism, was 57.1 +/- 4.5 and 29.4 +/- 3.8 nmol/min per mg of protein for control and propylthiouracil-treated animals respectively. Administration of tri-iodothyronine resulted in an approx. 4.5-fold increase in dehydrogenase activity in propylthiouracil-treated animals. A dose-dependent increase in hepatic GSH S-transferase activity in propylthiouracil-treated animals was observed at tri-iodothyronine concentrations ranging from 2 to 200 micrograms/100 g body wt. This increase in transferase activity was seen only when 1,2-epoxy-3-(p-nitrophenoxy)propane was used as substrate for the transferase. Transferase activity with 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene as substrate was decreased by tri-iodothyronine. Administration of actinomycin D (75 micrograms/100 g body wt.) inhibited the tri-iodothyronine induction of transferase activity. Results of these studies strongly suggest that tri-iodothyronine administration markedly affected the activities of GSH S-transferase by inducing a specific isoenzyme of GSH S-transferase and suppressing other isoenzymic activities.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-14284758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-18337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-218285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-345769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-363262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-4107711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-4436300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-4634012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-4639029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-474272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-476129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-4986007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-5552409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-6278195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-6736013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-6790531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-6946422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-7107616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-7378056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-7387737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-830423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-958327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954756-971518
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
233
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
595-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3954756-Animals,
pubmed-meshheading:3954756-Dactinomycin,
pubmed-meshheading:3954756-Enzyme Induction,
pubmed-meshheading:3954756-Epoxy Compounds,
pubmed-meshheading:3954756-Female,
pubmed-meshheading:3954756-Glutathione Transferase,
pubmed-meshheading:3954756-Hypothyroidism,
pubmed-meshheading:3954756-Liver,
pubmed-meshheading:3954756-Mice,
pubmed-meshheading:3954756-Mice, Inbred C57BL,
pubmed-meshheading:3954756-Nitrophenols,
pubmed-meshheading:3954756-Propylthiouracil,
pubmed-meshheading:3954756-Triiodothyronine
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pubmed:year |
1986
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pubmed:articleTitle |
Stimulation of mouse liver glutathione S-transferase activity in propylthiouracil-treated mice in vivo by tri-iodothyronine.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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