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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0000975,
umls-concept:C0001563,
umls-concept:C0001675,
umls-concept:C0017054,
umls-concept:C0024554,
umls-concept:C0032105,
umls-concept:C0205191,
umls-concept:C0205307,
umls-concept:C0441889,
umls-concept:C0681850,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C1707455,
umls-concept:C2003941,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
3
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pubmed:dateCreated |
1986-4-4
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pubmed:abstractText |
Vitamin E was administered orally (400 IU twice a day) to adult male humans for 28 days as either dl-alpha-tocopheryl acetate (all-rac-alpha-tocopheryl acetate) or d-alpha-tocopheryl acetate (RRR-alpha-tocopheryl acetate). Plasma alpha-tocopherol rose rapidly and fell at the same rate following cessation of supplementation with both forms of vitamin E. No significant differences in plasma alpha- or gamma-tocopherol levels were found between the two forms of vitamin E following their administration. The results confirm the currently accepted biopotencies of 1.0 IU/mg and 1.36 IU/mg, respectively for the two forms of vitamin E. Supplementation with either form of alpha-tocopheryl acetate resulted in depressing plasma gamma-tocopherol to less than 1/3 of initial levels; also the gamma/alpha ratio was depressed to less than 1/7 of the initial value. The study suggests that the gamma/alpha vitamin E ratio might also serve as a sensitive index of alpha-tocopherol ingestion.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-9165
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
382-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3953477-Administration, Oral,
pubmed-meshheading:3953477-Adolescent,
pubmed-meshheading:3953477-Adult,
pubmed-meshheading:3953477-Biological Availability,
pubmed-meshheading:3953477-Double-Blind Method,
pubmed-meshheading:3953477-Humans,
pubmed-meshheading:3953477-Kinetics,
pubmed-meshheading:3953477-Lipids,
pubmed-meshheading:3953477-Male,
pubmed-meshheading:3953477-Middle Aged,
pubmed-meshheading:3953477-Random Allocation,
pubmed-meshheading:3953477-Stereoisomerism,
pubmed-meshheading:3953477-Tocopherols,
pubmed-meshheading:3953477-Vitamin E,
pubmed-meshheading:3953477-alpha-Tocopherol
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pubmed:year |
1986
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pubmed:articleTitle |
Comparison of plasma alpha and gamma tocopherol levels following chronic oral administration of either all-rac-alpha-tocopheryl acetate or RRR-alpha-tocopheryl acetate in normal adult male subjects.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial
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