Linked Life Data

3943925

Source:http://linkedlifedata.com/resource/pubmed/id/3943925

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-3-13
pubmed:abstractText
A type-D retrovirus, derived from a human cell line and designated PMFV, which is related to, but distinct from the Mason-Pfizer monkey virus (MPMV) suppressed the in vitro mitogen response of human lymphocytes. PMFV was suppressive either as intact virus or after disruption by ether or detergents. In kinetic studies, the time course of the interaction between suppressive virus components and lymphocytes was characterized. Neither cytotoxicity nor time shifts in optimum 3H-thymidine incorporation of responding lymphocytes were observed. The suppressive activity of the disrupted virus was diminished by heating, freeze-thawing or treatment with pronase or trypsin, indicating temperature-sensitive proteins as suppressive components. By Sephacryl S-200 gel chromatography, molecular weights of approximately 70 and 15 kDa were determined for the suppressive components which were isolated from disrupted virus or virus-producing cells but not from non-infected cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0020-7136
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Suppression of human lymphocyte mitogen response by proteins of the type-D retrovirus PMFV.
pubmed:publicationType
Journal Article