Linked Life Data

3936720

Source:http://linkedlifedata.com/resource/pubmed/id/3936720

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1986-3-6
pubmed:abstractText
The study of the immunology of schistosomiasis has allowed a clear understanding of the basic mechanisms of resistance, emphasizing the important role played by cellular and humoral factors. Whereas the production of polyclonal or monoclonal antibodies and the precise inventory of immune effector mechanisms in the rat and in man have led to the identification of potentially protective antigens, immunization with soluble schistosome components has not allowed a successful control of the destruction of schistosomula after infection. The experiments reported here show that schistosomulum-released products (SRP) were able to induce the production of antibodies, in the rat and the monkey, highly cytotoxic in antibody-dependent cellular cytotoxicity, using monocyte monolayers, platelets or eosinophils as effector cells. The immunization of rats with either total SRP or 25-30-kDa molecules purified from schistosomula conferred a significant protection towards a challenge infection by the parasite. IgE and to a lesser extent IgG antibodies represented the major humoral factors of cell activation leading to the schistosomulum killing when anti-SRP antisera, obtained after immunization of the monkey, were incubated with human effector cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1168-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Defined antigens secreted by the larvae of schistosomes protect against schistosomiasis: induction of cytotoxic antibodies in the rat and the monkey.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't