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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0032005,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0036536,
umls-concept:C0036537,
umls-concept:C0167626,
umls-concept:C0205160,
umls-concept:C0392747,
umls-concept:C0443252,
umls-concept:C0457454,
umls-concept:C0733758,
umls-concept:C1280500,
umls-concept:C1444662,
umls-concept:C1446409,
umls-concept:C1533691
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pubmed:issue |
3
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pubmed:dateCreated |
1985-12-23
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pubmed:abstractText |
The effect of pretreatment in vivo with oestradiol benzoate on in vitro secretion of LH and FSH was studied in long-term ovariectomized (OVX) rats both at the end of a 5-day continuous in vivo pretreatment with LRH and 4-days after cessation of such LRH pretreatment. Rats were on day 0 sc implanted with osmotic minipumps which released LRH at the rate of 250 ng/h. Control rats were implanted with a piece of silicone elastomer with the dimensions of a minipump. On days 2 and 4 the rats were injected with either 3 micrograms EB or with oil. On day 5 part of the rats were decapitated and the in vitro autonomous (i.e. non-LRH-stimulated) and 'supra-maximally' LRH-stimulated release of LH and FSH was studied using a perifusion system. From other rats the minipumps were removed on day 5 and perifusion was performed on day 9. On the 5th day of the in vivo LRH pretreatment the pituitary LH/FSH stores were partially depleted; the pituitaries of the EB-treated rats more so than those of the oil-injected rats. EB alone had no significant effect on the content of the pituitary LH- and FSH stores. On day 9, i.e. 4 days after removal of the minipumps, the pituitary LH and FSH contents had increased in both the oil- and the EB injected rats, but had not yet recovered to control values. In rats not subjected to the 5-days pretreatment with LRH EB had a positive effect on the supra-maximally LRH-stimulated secretion of LH and FSH as well as on the non-stimulated secretion of LH. EB had no effect on the non-stimulated secretion of FSH.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drug Implants,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Follicle Stimulating Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Gonadotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0001-5598
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
329-37
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3934893-Animals,
pubmed-meshheading:3934893-Drug Implants,
pubmed-meshheading:3934893-Estradiol,
pubmed-meshheading:3934893-Female,
pubmed-meshheading:3934893-Follicle Stimulating Hormone,
pubmed-meshheading:3934893-Gonadotropin-Releasing Hormone,
pubmed-meshheading:3934893-Luteinizing Hormone,
pubmed-meshheading:3934893-Ovariectomy,
pubmed-meshheading:3934893-Perfusion,
pubmed-meshheading:3934893-Pituitary Gland,
pubmed-meshheading:3934893-Rats,
pubmed-meshheading:3934893-Rats, Inbred Strains,
pubmed-meshheading:3934893-Time Factors
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pubmed:year |
1985
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pubmed:articleTitle |
The depressing (negative) effect of oestradiol benzoate on the in vitro secretion of LH and FSH by the pituitary gland of the LRH-pretreated long-term ovariectomized rat changes into the augmentative (positive) effect after discontinuation of the LRH-pretreatment.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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