Linked Life Data

3934615

Source:http://linkedlifedata.com/resource/pubmed/id/3934615

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-1-23
pubmed:abstractText
The purpose of this study was to compare and characterize histopathologically the virulence of two bacterial strains in a naturally susceptible animal host. One of the strains Pseudomonas aeruginosa ATCC 19660, routinely used in this laboratory, produces endopthalmitis and phthisis bulbi in C57BL/6 mice within 3-4 weeks. The other bacterial strain, a clinical isolate from a 70-year-old patient with Pseudomonas corneal infection was found to be less virulent in the patient and thus was examined for virulence in the susceptible mouse model. The strain also proved to be less virulent in the normally susceptible mouse when compared with ATCC 19660. In general, when comparing the histopathological response of the mice to the two bacterial strains, it was found that in contrast to ATCC 19660, fewer polymorphonuclear neutrophils migrated into the cornea at 24-72 h, endothelial and epithelial necrosis was delayed, few free bacteria were observed in the cornea and animals recovered corneal clarity by 21-25 days following infection.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0030-3747
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-96
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Pseudomonas aeruginosa induced ocular infection. A histological comparison of two bacterial strains of different virulence.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.