Linked Life Data

3933537

Source:http://linkedlifedata.com/resource/pubmed/id/3933537

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1985-12-24
pubmed:abstractText
The effects of high-dose indomethacin (three daily dose, 8.5 mg/kg ip) on pathology and histology, on serum and urine biochemistry, and on various hepatic enzyme activities were studied in rats. Hepatic cytochrome P-450 and aminopyrine N-demethylase were decreased by 52-62%, but glucuronyl transferase fell by only 22%. Hepatic glucose-6-phosphatase, aryl esterase, 6-phosphogluconate dehydrogenase and sulphotransferase remained unchanged, while glucose-6-phosphate dehydrogenase increased by 29%. There were no widespread changes in hepatic and renal pathology or histology, but noteworthy was a mild, focal, centrilobular hepatic response. By contrast, there were severe intestinal lesions: the effects on hepatic enzymes might have been partly a consequence of the intestinal damage. There was a reversible uraemia and significant decreases (20-40% below normal) in both serum albumin and protein, while serum levels of creatinine and aspartate-amino-transferase activity remained constant. A reversible N-acetyl-beta-D-glucoseaminidase (NAG) enzymuria occurred (300% above normal), but no significant proteinuria (less than 300 mg/l). Administration of 16, 16-dimethylprostaglandin F2 alpha(0.5 mg/kg iv) concomitantly with the indomethacin greatly ameliorated the intestinal lesions and prevented the decreases in hepatic drug-metabolizing enzymes. Concomitant 16,16-dimethylprostaglandin F2 alpha did not, however, influence the indomethacin-induced decreases in serum protein, albumin or NAG-enzymuria. It was concluded that indomethacin had a highly selective effect causing a decrease in hepatic cytochrome P-450, which was not accompanied by severe damage to hepatocyte structure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0007-1021
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
527-34
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:3933537-Acetylglucosaminidase, pubmed-meshheading:3933537-Aminopyrine N-Demethylase, pubmed-meshheading:3933537-Animals, pubmed-meshheading:3933537-Cytochrome P-450 Enzyme System, pubmed-meshheading:3933537-Dinoprost, pubmed-meshheading:3933537-Dose-Response Relationship, Drug, pubmed-meshheading:3933537-Glucosephosphate Dehydrogenase, pubmed-meshheading:3933537-Glucuronosyltransferase, pubmed-meshheading:3933537-Indomethacin, pubmed-meshheading:3933537-Intestines, pubmed-meshheading:3933537-Kidney, pubmed-meshheading:3933537-Kidney Function Tests, pubmed-meshheading:3933537-Liver, pubmed-meshheading:3933537-Liver Function Tests, pubmed-meshheading:3933537-Male, pubmed-meshheading:3933537-Prostaglandins F, Synthetic, pubmed-meshheading:3933537-Rats, pubmed-meshheading:3933537-Rats, Inbred Strains, pubmed-meshheading:3933537-Serum Albumin, pubmed-meshheading:3933537-Uremia
pubmed:year
1985
pubmed:articleTitle
Comparative effects of indomethacin on hepatic enzymes and histology and on serum indices of liver and kidney function in the rat.
pubmed:publicationType
Journal Article, Comparative Study