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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1985-11-12
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pubmed:abstractText |
The paper discusses the importance and implications of the event-related-potentials in the analysis of effects of centrally acting drugs. This is illustrated using a study on the influence of diazepam and caffeine on the contingent-negative-variation (CNV) as an example. Special emphasis is placed on methodological problems and their possible solutions. A linear robust fitting technique was used for quantification of the slow-rising, ramp-like CNV potentials as an alternative to conventional baseline-to-peak measures. Results obtained by this method were validated by a second analysis taking slow superimposed DC-shifts into account. This was achieved by defining a reference line from the data for CNV-development and -resolution. The possibilities of single-trial potential evaluation were explored by using a pattern recognition algorithm. The average CNV-waveform was used as a reference-signal to which the single-trial potentials were correlated. Since pattern recognition techniques are sensitive to morphological changes of the potentials they are adding a new aspect to event-related-potential analysis.
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pubmed:language |
ger
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0012-7590
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
69-74
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading | |
pubmed:year |
1985
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pubmed:articleTitle |
[Methodological aspects of the analysis of the effects of drugs (diazepam and caffeine) on contingent negative variation].
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pubmed:publicationType |
Journal Article,
English Abstract
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