Linked Life Data

3928770

Source:http://linkedlifedata.com/resource/pubmed/id/3928770

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-10-9
pubmed:abstractText
The role of lipopolysaccharide (LPS) in determining the permeability of the outer membrane of Pseudomonas aeruginosa to carbenicillin and gentamicin was investigated. The susceptibility of P. aeruginosa isolates to smooth LPS-specific phages and to pyocin R1 gave indirect evidence of an altered LPS structure in strains resistant to carbenicillin, gentamicin, or both. Some secondary mutation, however, also appeared to be required for acquisition of the antibiotic-resistant phenotype. Phage- and pyocin-resistant variants demonstrating both wild-type and mutant responses to the drugs were subsequently isolated. Four-, eight-, and 16-fold increases in resistance to carbenicillin, supersusceptible responses to gentamicin, or both, were associated with a number of the LPS-altered mutants. The results supported the hypothesis that a primary mutation involving LPS, in combination with some undefined secondary mutation, determines the permeability of the outer membrane to carbenicillin and to gentamicin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
351-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Pseudomonas aeruginosa: evidence for the involvement of lipopolysaccharide in determining outer membrane permeability to carbenicillin and gentamicin.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't