Linked Life Data

3927175

Source:http://linkedlifedata.com/resource/pubmed/id/3927175

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-9-19
pubmed:abstractText
The possible central regulation of cardiovascular system by serotoninergic neurones was investigated in rats by using a cross-circulated head preparation. Intracarotid injections of serotonin (5-HT, 0.1-10 micrograms) consistently produced neurally mediated vasodepression in the recipient body. Although intravenous injections of 5-HT (0.1-1 micrograms) caused similar depressor responses, larger doses (5-10 micrograms) caused biphasic responses, consisting of vasodepression followed by a sustained pressor response. Despite the biphasic blood pressure responses, sympathetic nerve activity was consistently reduced by the intravenous 5-HT. Bilateral vagotomy abolished the vasodepressor responses to intravenous injections of 5-HT (10 micrograms) and made the responses purely pressor, but the vasodepressor responses to intracarotid injections of 5-HT (10 micrograms) were largely unaffected. Following destruction of central noradrenergic neurones by intracerebroventricular injections of 6-hydroxydopamine, the vasodepressor responses to intracarotid 5-HT (1-10 micrograms), but not to the intravenous 5-HT, were significantly reduced. These results suggest that intravenous injections of 5-HT reduce nerve activity by affecting the reflex mechanism via the vagus nerves. On the other hand, the vasodepression and reduction of the nerve activity by the intracarotid injections appears to be of central origin, and the vasodepression could be mediated via noradrenergic mechanisms in the brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0028-1298
pubmed:author
pubmed:issnType
Print
pubmed:volume
329
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
222-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Cardiovascular and sympathetic responses to intracarotid and intravenous injections of serotonin in rats.
pubmed:publicationType
Journal Article