| pubmed-article:3924428 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3924428 | lifeskim:mentions | umls-concept:C0007090 | lld:lifeskim |
| pubmed-article:3924428 | lifeskim:mentions | umls-concept:C0015780 | lld:lifeskim |
| pubmed-article:3924428 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3924428 | lifeskim:mentions | umls-concept:C0929301 | lld:lifeskim |
| pubmed-article:3924428 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:3924428 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:3924428 | lifeskim:mentions | umls-concept:C0000248 | lld:lifeskim |
| pubmed-article:3924428 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:3924428 | lifeskim:mentions | umls-concept:C1979928 | lld:lifeskim |
| pubmed-article:3924428 | lifeskim:mentions | umls-concept:C1880989 | lld:lifeskim |
| pubmed-article:3924428 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3924428 | pubmed:dateCreated | 1985-8-1 | lld:pubmed |
| pubmed-article:3924428 | pubmed:abstractText | We determined UDP-glucuronyltransferase (UDP-GT) activities of hepatic and mammary gland microsomes of female rats with p-nitrophenol and the ring- and N-hydroxylated metabolites of N-2-fluorenylacetamide (2-FAA) and the effects of hepatic inducers of UDP-GT's on these glucuronidations. Pre-treatment of non-lactating (NL) and lactating (L) rats with beta-naphthoflavone (beta-NF) significantly increased glucuronidations, of p-nitrophenol, the phenolic metabolites of 2-FAA, especially of 5-hydroxy-2-FAA, and also of N-hydroxy-2-FAA by hepatic microsomes. Pre-treatment of L rats with beta-NF or 3-methyl-cholanthrene (3-MC) significantly increased glucuronidations of these compounds by mammary gland microsomes suggesting that both liver and mammary gland of L rats possess similar UDP-GT activities. In NL rats, UDP-GT activities of mammary microsomes toward phenols were greater than in L rats, and except for that of 5- and 7-hydroxy-2-FAA, were not inducible with beta-NF. The data obtained with L rats, the greater magnitude of stimulation of the hepatic UDP-GT of NL rats by beta-NF than by phenobarbital, and the lack of effect of the latter on UDP-GT of mammary microsomes suggested that the phenolic metabolites of 2-FAA and N-hydroxy-2-FAA share chiefly the characteristics of substrates for group 1 UDP-GT activities (i.e., those inducible with beta-NF or 3-MC). Neither inducer increased glucuronidation of 9-hydroxy-2-FAA, a relatively poor substrate for UDP-GT of mammary or hepatic microsomes. In contrast to hepatic microsomes which formed considerable amounts of the glucuronide of N-hydroxy-2-FAA, mammary gland microsomes glucuronidated this substrate to a minor extent only. This suggested that glucuronide of N-hydroxy-2-FAA may play a role in systemic, but not in local mammary tumorigenesis by N-hydroxy-2-FAA. | lld:pubmed |
| pubmed-article:3924428 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3924428 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3924428 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3924428 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3924428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3924428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3924428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3924428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3924428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3924428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3924428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3924428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3924428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3924428 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3924428 | pubmed:month | May | lld:pubmed |
| pubmed-article:3924428 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:3924428 | pubmed:author | pubmed-author:RyzewskiC NCN | lld:pubmed |
| pubmed-article:3924428 | pubmed:author | pubmed-author:Malejka-Gigan... | lld:pubmed |
| pubmed-article:3924428 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3924428 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:3924428 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3924428 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3924428 | pubmed:pagination | 687-92 | lld:pubmed |
| pubmed-article:3924428 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3924428 | pubmed:meshHeading | pubmed-meshheading:3924428-... | lld:pubmed |
| pubmed-article:3924428 | pubmed:meshHeading | pubmed-meshheading:3924428-... | lld:pubmed |
| pubmed-article:3924428 | pubmed:meshHeading | pubmed-meshheading:3924428-... | lld:pubmed |
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| pubmed-article:3924428 | pubmed:meshHeading | pubmed-meshheading:3924428-... | lld:pubmed |
| pubmed-article:3924428 | pubmed:meshHeading | pubmed-meshheading:3924428-... | lld:pubmed |
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| pubmed-article:3924428 | pubmed:meshHeading | pubmed-meshheading:3924428-... | lld:pubmed |
| pubmed-article:3924428 | pubmed:meshHeading | pubmed-meshheading:3924428-... | lld:pubmed |
| pubmed-article:3924428 | pubmed:meshHeading | pubmed-meshheading:3924428-... | lld:pubmed |
| pubmed-article:3924428 | pubmed:meshHeading | pubmed-meshheading:3924428-... | lld:pubmed |
| pubmed-article:3924428 | pubmed:meshHeading | pubmed-meshheading:3924428-... | lld:pubmed |
| pubmed-article:3924428 | pubmed:meshHeading | pubmed-meshheading:3924428-... | lld:pubmed |
| pubmed-article:3924428 | pubmed:meshHeading | pubmed-meshheading:3924428-... | lld:pubmed |
| pubmed-article:3924428 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3924428 | pubmed:articleTitle | Microsomal metabolism of the carcinogen, N-2-fluorenyl-acetamide, by the mammary gland and liver of female rats. II. Glucuronidation of ring- and N-hydroxylated metabolites of N-2-fluorenylacetamide. | lld:pubmed |
| pubmed-article:3924428 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3924428 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3924428 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3924428 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
