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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6009
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pubmed:dateCreated |
1985-5-10
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pubmed:abstractText |
Two genes that code for a hapten-specific immunoglobulin M (IgM) have been introduced into the mouse germ line. The transgenic antibody represents 10-50% of the serum IgM and is expressed on the membrane of B cells. B-cell hybridoma lines show that a negative feedback inhibition of mu and kappa transgenic products on the immunoglobulin heavy-chain rearrangement is possible.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0028-0836
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
314
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
330-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3920529-Alleles,
pubmed-meshheading:3920529-Animals,
pubmed-meshheading:3920529-Base Sequence,
pubmed-meshheading:3920529-DNA, Recombinant,
pubmed-meshheading:3920529-Gene Expression Regulation,
pubmed-meshheading:3920529-Genes,
pubmed-meshheading:3920529-Hybridomas,
pubmed-meshheading:3920529-Immunoglobulin Heavy Chains,
pubmed-meshheading:3920529-Immunoglobulin Light Chains,
pubmed-meshheading:3920529-Immunoglobulin kappa-Chains,
pubmed-meshheading:3920529-Immunoglobulin mu-Chains,
pubmed-meshheading:3920529-Mice,
pubmed-meshheading:3920529-Plasmids,
pubmed-meshheading:3920529-RNA, Messenger,
pubmed-meshheading:3920529-Recombination, Genetic
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pubmed:articleTitle |
Transmission and expression of a specific pair of rearranged immunoglobulin mu and kappa genes in a transgenic mouse line.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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