|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1985-3-19
|
|
pubmed:abstractText |
In order to study the possible role of the T-lymphocyte growth factor, Interleukin 2 (IL-2), and/or of the IL-2 receptor in the autonomous growth of leukaemic cells, 15 mouse leukaemic cell lines of various aetiology were analyzed for (i) IL-2 receptor expression and (ii) for the capacity to secrete IL-2. Several but not all of the cell lines tested were IL-2 receptor positive. The cells constitutively expressing IL-2 receptors at their surface could not be stimulated to secrete IL-2. Cell producing and secreting IL-2 did not express detectable amounts of IL-2 receptors at their surface. It has been demonstrated that proliferation of the leukaemic cells was independent of exogenous IL-2. The monoclonal anti-IL-2 receptor antibody AMT-13 inhibited IL-2 dependent proliferation of activated normal T-lymphocytes but failed to inhibit the growth of IL-2 receptor expressing leukaemic cells. The results argue against the autocrine stimulation hypothesis but do not exclude the possibility of involvement of functionally altered IL-2 receptors on autonomous cell growth.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-314938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-6167655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-6212257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-6286010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-6373015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-6403081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-6409189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-6450160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-6455129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-6606011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-6961115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-6972903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-7042543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917677-761943
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0007-0920
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
51
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
23-30
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3917677-Animals,
pubmed-meshheading:3917677-Antibodies, Monoclonal,
pubmed-meshheading:3917677-Cell Division,
pubmed-meshheading:3917677-Cell Line,
pubmed-meshheading:3917677-Interleukin-2,
pubmed-meshheading:3917677-Leukemia, Experimental,
pubmed-meshheading:3917677-Mice,
pubmed-meshheading:3917677-Mice, Inbred Strains,
pubmed-meshheading:3917677-Receptors, Immunologic,
pubmed-meshheading:3917677-Receptors, Interleukin-2,
pubmed-meshheading:3917677-T-Lymphocytes
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Studies on interleukin 2 receptor expression and IL-2 production by murine T cell lymphomas.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
