Linked Life Data

3915179

Source:http://linkedlifedata.com/resource/pubmed/id/3915179

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1986-7-10
pubmed:abstractText
Phagocytic killing of group B streptococci serotypes Ia, Ib, IIR- (R protein negative), IIR+ (R protein positive), IIIR- and IIIR+ by human granulocytes was studied after opsonization in properdin deficient serum, pooled normal human serum and in selected sera with high or low concentrations of antibody to group B streptococci. All serotypes were killed by granulocytes after opsonization in normal serum, but serotype IIIR- was comparatively resistant. Properdin deficient serum showed no opsonic activity for type IIIR-. A reduced opsonic capacity of properdin deficient serum for serotypes Ib and IIR+ was demonstrated, whereas the other serotypes were efficiently opsonized. The reduced or absent opsonic activity of properdin deficient serum could be restored by addition of purified properdin. Antibody levels did not appear to be limiting in the assay system. Blocking of C1 activation with MgEGTA in normal serum delayed, but did not abolish opsonization of the various group B streptococcal serotypes, while the opsonic activity in chelated properdin deficient serum was markedly reduced. Taken together, the findings suggest that an intact classical pathway is crucial in group B streptococcal opsonization. However, efficient opsonization of some strains apparently requires that C3 activation on the bacterial surface is amplified through recruitment of the alternative pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0108-0202
pubmed:author
pubmed:issnType
Print
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
251-6
pubmed:dateRevised
2009-6-4
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Opsonization of group B streptococci in properdin deficient serum.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't