Linked Life Data

3904225

Source:http://linkedlifedata.com/resource/pubmed/id/3904225

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1985-12-19
pubmed:abstractText
Prostacyclin is the most potent inhibitor of platelet aggregation and a very strong vasodilator. A few reports on a moderate vasoconstrictory response in certain vascular segments in various species have received less attention. We demonstrated recently that PGI2 dilates the arterial wall and has a constrictory effect on the venous wall. Normal and varicose human veins show a dose-dependent constrictory response to PGI2. Pretreatment of patients with 2.5 mg dihydroergotamine t.i.d. for 10 days increases venous PGI2 synthesis significantly. In vitro contractility response is identical in normal and varicose veins. Furthermore, no difference in contractility was registered in veins derived from treated and untreated patients. The significantly enhanced formation of PGI2 evoked by dihydroergotamine might be responsible for the tonisation of normal, healthy veins, as well as varicose veins.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0043-5325
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
817-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
[Is the tonisation of varicose veins due to elevated prostacyclin synthesis caused by dihydroergotamine?].
pubmed:publicationType
Journal Article, English Abstract