Linked Life Data

3903489

Source:http://linkedlifedata.com/resource/pubmed/id/3903489

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-12-2
pubmed:abstractText
The localization of myoglobin (Mb) in skeletal muscle in various neuromuscular diseases was studied by an immunoperoxidase technique. The immunoreactivity of Mb was shown to be well preserved in muscle fibers that showed denervation atrophy or vacuolar degeneration, as well as in muscle fibers with apparently normal structure. Marked decrease or loss of Mb immunoreactivity was observed in muscle fibers with hyaline degeneration or floccular necrosis, where there was irreversible disruption of the muscle fibers. On the other hand, regenerated fibers showed variable immunostaining for Mb. Most regenerated fibers showed little or no immunostaining but some showed staining as strong as apparently normal fibers. These findings in various neuromuscular diseases suggested that the elevation of serum Mb in patients with these diseases was ascribed to its release from severely injured, necrotic muscle fibers. The immunohistochemistry for Mb was shown to be useful to evaluate plasma membrane injury and characterize muscle degeneration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0148-639X
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9-16
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Immunohistochemical study of myoglobin in neuromuscular diseases.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't