Linked Life Data

3881636

Source:http://linkedlifedata.com/resource/pubmed/id/3881636

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-3-21
pubmed:abstractText
Immunologically mediated tissue lesions or functional disturbances can result from immune responses either to foreign antigens or autoantigenic constituents. Before a disease or a functional disorder can be called an (auto)immune disease, it must be established that immunological processes are involved in its etiology and/or pathogenesis. After reviewing the available data on immunology and on research on immunobiology of the inner ear, as well as clinical observations on disorders of the inner ear of possibly immunological origin, an attempt is made to determine whether (auto)immunopathology can be assumed in some patients with sensineural hearing loss. In patients with disorders presently recognized as autoimmune diseases, no hearing loss has been described so far. However, serum antibodies can be found via the indirect immunofluorescence method in some patients having functional disorders of the inner ear. These serum antibodies interact with normal human inner ear tissue. However, as long as immunopathological mechanisms have not been confirmed, these disorders should merely be called "diseases with autoimmune markers." It has been shown in animal experiments that the production of autoantibodies against inner ear components is associated with morphological and functional changes of the inner ear. The human endolymphatic sac releases secretory IgA into the lumen. Its epithelium contains (intraepithelial) lymphocytes, whereas lymphocytes, plasma cells (IgA, IgG) and macrophages occur in the perisaccular region. In this manner, the inner ear has its own immune system, which can possibly react independently of the systemic immune system.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0340-1588
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
[Immunopathology of the inner ear].
pubmed:publicationType
Journal Article, English Abstract