3881323

Source:http://linkedlifedata.com/resource/pubmed/id/3881323

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0008312, umls-concept:C0008976, umls-concept:C0013072, umls-concept:C0030705, umls-concept:C0030817, umls-concept:C2587213
pubmed:issue	2
pubmed:dateCreated	1985-3-21
pubmed:abstractText	One hundred and eighty nine patients with primary biliary cirrhosis were entered into a double blind, placebo controlled randomised trial starting in January 1978 to assess the therapeutic value of d-penicillamine 1200 mg daily. Eighteen of the 98 patients receiving d-penicillamine and 22 of the 91 placebo treated patients died during the study. Thirty six per cent of those on d-penicillamine and 8% of those on placebo were withdrawn from the study. No difference in overall survival was noted between the two groups of patients whether the results were analysed for the entire period of observation or only during the period in which the patients were receiving therapy. The mortality rate of those receiving d-penicillamine in histological stage I to II, however, was one third of that of the placebo group although this difference did not reach statistical significance. Using the occurrence rate ratio as the statistical method of analysis, no effect of d-penicillamine was noted on any clinical, biochemical or histological features examined, except the serum alanine aminotransferase activity which was greater in those on active treatment. In this trial we have been unable to establish any therapeutic benefit from the drug.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-14353274, http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-428825, http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-46538, http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-5780841, http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-5947845, http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-6112602, http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-6212278, http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-67338, http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-6847917, http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-6991353, http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-7033789, http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-7309888, http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-759879, http://linkedlifedata.com/resource/pubmed/commentcorrection/3881323-831755
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985108R
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Penicillamine
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0017-5749
pubmed:author	pubmed-author:CaballeriaJJ, pubmed-author:ChristensenEE, pubmed-author:NeubergerJJ, pubmed-author:PortmannBB, pubmed-author:RanekLL, pubmed-author:RodesJJ, pubmed-author:TygstrupNN, pubmed-author:WilliamsRR
pubmed:issnType	Print
pubmed:volume	26
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	114-9
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:3881323-Clinical Trials as Topic, pubmed-meshheading:3881323-Double-Blind Method, pubmed-meshheading:3881323-Humans, pubmed-meshheading:3881323-Liver Cirrhosis, Biliary, pubmed-meshheading:3881323-Penicillamine
pubmed:year	1985
pubmed:articleTitle	Double blind controlled trial of d-penicillamine in patients with primary biliary cirrhosis.
pubmed:publicationType	Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't