| pubmed-article:3879221 | pubmed:abstractText | [3H]MPP+ (1-[methyl-3H]4-phenylpyridinium) is taken up into rat striatal slices in a temperature-, time- and Na+-dependent process blocked by dopamine (DA) uptake inhibitors. Once taken up, authentic [3H]MPP+ is released at 37 degrees C by 15 mM KCl. This release is inhibited by (-)N-propyl-norapomorphine and enhanced by (-)sulpiride, as observed under the same conditions for [3H]DA release. Thus, rat striatal DA-ergic nerve endings do not discriminate between DA and MPP+ for their active transport and DA autoreceptor-regulated release. | lld:pubmed |
