Linked Life Data

3873281

Source:http://linkedlifedata.com/resource/pubmed/id/3873281

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-7-12
pubmed:abstractText
In a model consisting of noninbred rabbits matched for major histocompatibility antigens and mismatched for immunoglobulin allotypes, using cell donors and recipients unrelated to each other, B-cell memory has been demonstrated to persist through three successive transfers for a period approaching 2 years. Memory cells from the original donor are shown to dominate specific antibody responses of the primary and secondary recipients. Vigorous antibody responses by donor-derived cells are obtained even when antigenic stimulation is delayed by several months. The data suggest that B memory cells may be particularly efficient in the colonization of recipients, and the potential significance of these findings for adoptive immunization of human bone marrow recipients is discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0008-8749
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
385-96
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Immunocompetence of chimeric rabbits. III. Serial passage and persistence of B-lymphocyte memory.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't