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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1985-8-21
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pubmed:abstractText |
Tissue contents of prostaglandins (PG) PGE2, PGE2a and 6-keto-PGF1a (degradation product of PGI2) were determined in specimens of advanced human ovarian cancer (n = 11). The PG levels (ng/mg tissue protein) varied widley: PGE2 17-515; PGF2a 2-43 and 6-keto-PGF1a 5-105. Tumors of patients without response to chemotherapy contained more PGE2, PGF2a and 6-keto-PGF1a than did tumors responding to chemotherapy. PG production was investigated in two ovarian carcinoma-derived cell lines. The ability of these cells to synthesize PG varied depending on the cell density. An increase of cell number was associated with a decrease of PG yield. PG formation was inhibited by indomethacin in a concentration-dependent manner. The present study suggests that ovarian carcinoma cells form PG in vivo and vitro.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0090-6980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
665-72
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3859890-6-Ketoprostaglandin F1 alpha,
pubmed-meshheading:3859890-Adenocarcinoma,
pubmed-meshheading:3859890-Animals,
pubmed-meshheading:3859890-Cell Line,
pubmed-meshheading:3859890-Dinoprost,
pubmed-meshheading:3859890-Dinoprostone,
pubmed-meshheading:3859890-Female,
pubmed-meshheading:3859890-Humans,
pubmed-meshheading:3859890-Mice,
pubmed-meshheading:3859890-Mice, Nude,
pubmed-meshheading:3859890-Ovarian Neoplasms,
pubmed-meshheading:3859890-Prostaglandins,
pubmed-meshheading:3859890-Prostaglandins E,
pubmed-meshheading:3859890-Prostaglandins F
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pubmed:year |
1985
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pubmed:articleTitle |
Formation of prostaglandins by ovarian carcinomas.
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pubmed:publicationType |
Journal Article
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