Linked Life Data

3840583

Source:http://linkedlifedata.com/resource/pubmed/id/3840583

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1985-11-26
pubmed:abstractText
At a gestational age of 27.9 days, pregnant rabbits were infused with enprofylline, a new xanthine with potent antiasthmatic effects. Following a priming dose of 5 mg/kg, 20 mg/kg were infused over a 2-h period. Controls received Ringer's solution. On completion of the infusion, the fetuses were delivered and the effect on their surfactant system was evaluated. Surface tension in airway fluid, measured with the pulsating bubble surfactometer, at minimal bubble size in the third cycle, was 21.8 +/- 2.2 (mean +/- SE) versus 28.7 +/- 1.7 mN m-1 (p less than 0.01). Pressure-volume loops of the lungs of the fetuses showed that at a deflation pressure 10 cm H2O the volume was 64 +/- 3 versus 49 +/- 3% (p less than 0.0005). The lung lavage fluid had a phospholipid phosphorus content of 41.9 +/- 3.8 versus 18.5 +/- 1.3 micrograms/g dry lung (p less than 0.0005). The values indicate that enprofylline caused a release of surfactant into the fetal airways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0031-3998
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1000-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Pulmonary surfactant release in fetal rabbits as affected by enprofylline.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't