Linked Life Data

3838689

Source:http://linkedlifedata.com/resource/pubmed/id/3838689

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1985-6-10
pubmed:abstractText
We have investigated the effects of iontophoretically administered gamma-D-glutamylaminomethyl sulfonate (GAMS) on excitation of dorsal horn neurons and Renshaw cells of the cat spinal cord induced by exogenous excitants and by synaptic activation following stimulation of low threshold primary afferent fibers. Comparisons were made between the synaptic depressant effects of GAMS and those of gamma-D-glutamylglycine (gamma DGG) and (+/-)-2-amino-5-phosphonovalerate (APV). At low iontophoretic ejection currents, GAMS showed clear selectivity in antagonizing responses to excitatory amino acids in the order kainate greater than quisqualate greater than L-aspartate greater than NMDA greater than L-glutamate. This selectivity was decreased at high ejection currents, when acetylcholine-induced excitation of Renshaw cells was also reduced. GAMS was equieffective with gamma DGG in depressing both APV-sensitive polysynaptic excitation and APV-resistant monosynaptic excitation of spinal neurons. Ventral root evoked excitation of Renshaw cells was not reduced by GAMS. In some cells a depression of synaptic excitation by GAMS was observed in the absence of an effect on either L-glutamate- or L-aspartate-induced excitation. This raises the possibility that some other endogenous substance may be a transmitter acting at kainate/quisqualate type receptors in the cat spinal cord. However, other factors are discussed which may explain this observation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
327
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Depressant actions of gamma-D-glutamylaminomethyl sulfonate (GAMS) on amino acid-induced and synaptic excitation in the cat spinal cord.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't