Linked Life Data

3838374

Source:http://linkedlifedata.com/resource/pubmed/id/3838374

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-3-22
pubmed:abstractText
In an open prospective study, 40 women with severe recurrent vulvovaginal candidiasis were treated with ketoconazole 400 mg daily for two weeks, followed by prophylactic ketoconazole 400 mg daily for five days with onset of menses for three menstrual cycles. Initially, 100% of the women responded clinically, however, 24.3% developed recurrence of symptomatic candidal vaginitis during the period of cyclical prophylaxis. By the end of six months observation, 56.8% of the patients' symptoms had recurred; however, symptomatic recurrence during the next six months was uncommon. The clinical attack rate of symptomatic episodes was significantly reduced during the one-year observation. One patient developed reversible mild hepatitis on therapy. No evidence emerged that topical genital therapy of male partners was beneficial in reducing vaginal candida recolonization. Maintenance prophylactic therapy with oral ketoconazole appears effective in preventing recurrent episodes of vulvovaginal candidiasis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0029-7844
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
435-40
pubmed:dateRevised
2009-10-26
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Management of recurrent vulvovaginal candidiasis with intermittent ketoconazole prophylaxis.
pubmed:publicationType
Journal Article