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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0030842,
umls-concept:C0030844,
umls-concept:C0040676,
umls-concept:C0070625,
umls-concept:C0205289,
umls-concept:C0205296,
umls-concept:C0220781,
umls-concept:C0337112,
umls-concept:C0439851,
umls-concept:C0547040,
umls-concept:C1444754,
umls-concept:C1514873,
umls-concept:C1524075,
umls-concept:C1552596,
umls-concept:C1883254,
umls-concept:C1947931
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pubmed:issue |
12
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pubmed:dateCreated |
1987-4-10
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pubmed:abstractText |
In vitro synthesis of different natural penicillins (hexanoyl, heptanoyl and octanoyl-penicillin) have been carried out by direct acylation of 6-aminopenicillanic acid (6-APA) with several fatty acid-CoA derivatives (hexanoyl-CoA, heptanoyl-CoA and octanoyl-CoA). The reactions were catalyzed by the enzyme Acyl-CoA: 6-aminopenicillanic acid acyltransferase from Penicillium chrysogenum AS-P-78. This enzyme only accepts as substrate, aliphatic side chain precursors whose carbon length is between 6 and 8 atoms. Although the enzymatic synthesis of octanoylpenicillin has been previously reported the in vitro synthesis of hexanoyl and heptanoyl penicillins is described here for the first time.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Penicillin-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Penicillins,
http://linkedlifedata.com/resource/pubmed/chemical/acyl-CoA-6-aminopenicillanic acid...
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-8820
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1754-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading | |
pubmed:year |
1986
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pubmed:articleTitle |
Direct enzymatic synthesis of natural penicillins using phenylacetyl-CoA: 6-APA phenylacetyl transferase of Penicillium chrysogenum: minimal and maximal side chain length requirements.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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