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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1987-3-19
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pubmed:abstractText |
12-o-Tetradecanoylphorbol-13-acetate (TPA) activates calcium-activated, phospholipid-dependent protein kinase (protein kinase C) partially purified in an ion exchange column from pig epidermis. Protein kinase C was activated by TPA in a concentration-dependent manner with simultaneous addition of Ca2+ and phospholipid. Polyprenoic acid derivative (E5166) which is a newly synthesized retinoic acid derivative, inhibited the TPA activation of protein kinase C. This inhibition may explain the mechanisms by which retinoids inhibit TPA-induced tumor promotion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,7,11,15-tetramethyl-2,4,6,10,14-he...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylserines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin
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pubmed:status |
MEDLINE
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pubmed:issn |
0340-3696
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
279
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
50-3
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3813653-Animals,
pubmed-meshheading:3813653-Calcium,
pubmed-meshheading:3813653-Dose-Response Relationship, Drug,
pubmed-meshheading:3813653-Enzyme Activation,
pubmed-meshheading:3813653-Phosphatidylserines,
pubmed-meshheading:3813653-Protein Kinase C,
pubmed-meshheading:3813653-Skin,
pubmed-meshheading:3813653-Swine,
pubmed-meshheading:3813653-Tetradecanoylphorbol Acetate,
pubmed-meshheading:3813653-Tretinoin
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pubmed:year |
1986
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pubmed:articleTitle |
Effects of 12-o-tetradecanoylphorbol-13-acetate and polyprenoic acid derivative on calcium-activated phospholipid-dependent protein kinase of pig skin.
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pubmed:publicationType |
Journal Article
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