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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1987-2-26
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pubmed:abstractText |
Twice daily injection of caffeine (30 mg/kg) for 3-1/2 days shifted the caffeine stimulus generalization curve to the right by 3-fold in rats trained to discriminate saline from 30 mg/kg of caffeine, and by 4-fold in rats trained to discriminate saline from 10 mg/kg of caffeine. The latter group was also tested for cross-tolerance with methylphenidate, a drug that generalizes completely with caffeine. Twice daily injection of caffeine (30 mg/kg) for 3-1/2 days increased the ED50 of methylphenidate for caffeine-appropriate responding from 1.5 to 5.5 mg/kg. Conversely, injections of methylphenidate (3.0 mg/kg) increased the ED50 of caffeine from 5.2 to 15 mg/kg. The development of symmetrical cross-tolerance to the discriminative effects of caffeine and to the caffeine-like discriminative effects of methylphenidate supports previous observations suggesting commonalities in the cellular bases of the stimulus properties of these drugs.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0024-3205
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
381-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3807640-Animals,
pubmed-meshheading:3807640-Caffeine,
pubmed-meshheading:3807640-Discrimination Learning,
pubmed-meshheading:3807640-Drug Tolerance,
pubmed-meshheading:3807640-Generalization, Stimulus,
pubmed-meshheading:3807640-Male,
pubmed-meshheading:3807640-Methylphenidate,
pubmed-meshheading:3807640-Rats,
pubmed-meshheading:3807640-Rats, Inbred Strains
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pubmed:year |
1987
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pubmed:articleTitle |
Discriminative stimulus effects of caffeine: tolerance and cross-tolerance with methylphenidate.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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