Linked Life Data

3806257

Source:http://linkedlifedata.com/resource/pubmed/id/3806257

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-3-23
pubmed:abstractText
The long-term and short-term influence of large oral doses of ascorbic acid on the urinary excretion of calcium has been investigated. In the first experiment, daily doses of a total of 10 g of ascorbic acid were administered to healthy human subjects. Daily urinary samples of these subjects were collected before and during the treatment, and calcium contents of these samples were measured. Among the 22 subjects, 19 experienced no significant changes in urinary calcium levels during the ingestion of ascorbic acid, one subject experienced an increase, two had a decline. These changes in urinary calcium levels were relatively small and were within the changes from consuming normal diets. In the second experiment, urinary samples of 46 healthy subjects were collected during a period of 8 hours after the ingestion of 2 g of ascorbic acid (33 times the U.S. RDA). A significant increase in mean urinary calcium excretion from 48.2 +/- 25.1 mg to 58.3 +/- 28.0 mg in the 8-h time period was observed. Mean urinary volume and phosphorus were unchanged. Calcium levels of the initially low excretors were significantly elevated while the change in urinary calcium levels of the initially high excretors was not statistically significant following the administration of ascorbic acid. The results suggest that ascorbic acid has a short-term effect on the regulation of the absorption and metabolism of calcium in humans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0301-4800
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
437-46
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Effect of ascorbic acid on calcium elimination in humans.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't