Linked Life Data

3805977

Source:http://linkedlifedata.com/resource/pubmed/id/3805977

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-3-5
pubmed:abstractText
The effects of white noise and cocaine on squirrel monkeys' fixed-interval responding were compared to determine whether the presentation of an exteroceptive stimulus could produce rate-altering effects of the type typically observed following drug administration. To investigate the relationship between control response rate and response rate in the presence of drug or noise, the monkeys were trained under a fixed-interval 300-s stimulus-shock termination schedule in order to generate a wide range of local response rates. A light illuminated the experimental chamber during the interval and, after 300 s elapsed, a lever press during a 3-s period terminated the light and precluded the occurrence of a harmless electrical stimulus that otherwise was delivered at the end of the 3-s period. Each interval was followed by a 30-s timeout during which the chamber was darkened and responses had no consequences. Following intramuscular administration of cocaine, different rates of responding characteristic of control performance converged toward a common rate and, at an appropriately high dose, response rate during the fixed interval became more uniform. When white noise was presented continuously during a given session, different response rates also converged toward a common rate and, at an appropriate intensity, response rate became more uniform. Interactions were obtained when cocaine and white noise were presented together, indicating the possibility of a common behavioral mechanism of action. The results suggest that rate-altering drug effects may be, in part, a result of the ability of drugs to produce nonspecific stimulus effects similar to those observed for exteroceptive stimuli.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-113225, http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-113787, http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-13525481, http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-13952017, http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-14283987, http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-402028, http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-4205762, http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-4706233, http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-4762233, http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-5787400, http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-6547657, http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-804532, http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-944452, http://linkedlifedata.com/resource/pubmed/commentcorrection/3805977-959466
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-5002
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
381-94
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Similarities in the rate-altering effects of white noise and cocaine.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.