Linked Life Data

3805864

Source:http://linkedlifedata.com/resource/pubmed/id/3805864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-3-11
pubmed:abstractText
We investigated the possible role of platelet membrane vesicles on hemostatic function in vivo. Platelet membrane vesicles were prepared from rabbit platelets stored for up to 6 months at -65 degrees C and transfused into thrombocytopenic rabbits. Significant reductions in microvascular bleeding times were observed up to 24 hours after transfusion, with the greatest corrections at 4 hours. Measurements of factor V, factor VIII, fibrin degradation products, and fibrinogen in animals transfused with membrane ruled out intravascular coagulation and suggested a direct effect of platelet membrane vesicles at the bleeding sites. This conclusion was supported morphologically by identification of membrane vesicles in bleeding time lesions and radiologically by accumulation of 111In-labeled vesicles in lesions. Production of platelet membrane vesicles was simple, and freezing allowed long-term storage of a product capable of short-term hemostasis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-2143
pubmed:author
pubmed:issnType
Print
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Platelet membrane vesicles reduced microvascular bleeding times in thrombocytopenic rabbits.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.