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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0000189,
umls-concept:C0003320,
umls-concept:C0019169,
umls-concept:C0019721,
umls-concept:C0021311,
umls-concept:C0033684,
umls-concept:C0205191,
umls-concept:C0439849,
umls-concept:C0870432,
umls-concept:C1446409,
umls-concept:C1555465,
umls-concept:C1705417,
umls-concept:C1879547
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pubmed:issue |
12
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pubmed:dateCreated |
1987-3-18
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pubmed:abstractText |
In this study we have examined the density of HLA class I protein display on the hepatocytes of patients with HBe antigen (HBeAg) or anti-HBe (HBeAb) positive chronic hepatitis B virus (HBV) infection and related this to the level of interferon activation of these cells determined by measuring hepatic oligo 2-5A synthetase activity. In HBeAg positive patients the density of HLA class I (HLA-I) protein was not significantly increased above that found in uninfected liver, but levels of 2-5A synthetase were twice normal. In anti-HBe positive patients, HLA-I density was markedly increased in the presence of normal 2-5A synthetase activity. These data are consistent with type I (alpha or beta) interferon activation of the hepatocytes in HBeAg positive patients and type II (gamma) interferon activity in anti-HBe positive subjects.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-17838106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-2423427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-4555144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-6172715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-6180051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-6180680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-6182252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-6190592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-6193915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-6290893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-667938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-6848402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-6982941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-7095559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-7118068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3804026-83651
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0017-5749
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1498-501
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
|
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pubmed:year |
1986
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pubmed:articleTitle |
Relationship of HLA protein display to activation of 2-5A synthetase in HBe antigen or anti-HBe positive chronic HBV infection.
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pubmed:publicationType |
Journal Article
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