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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1987-3-9
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pubmed:abstractText |
Guinea pig fat cell membranes (FCM) have been widely used in preference to thyroid membranes as a source of TSH receptors to investigate TSH receptor antibodies in Graves' disease, because FCM are ostensibly free of other thyroid antigens. However, by FCM immunoblotting we have found: 8 of 10 normal sera bound to determinants at 38 and 190 kDa; 17 other determinants were recognised by 60% of Graves' or Hashimoto sera and by 20% of normal sera; three determinants at 65-90 kDa were recognised by 5 of 13 Graves' but by none of the normal or Hashimoto sera; and none of the determinants recognised appeared to be related to the TSH receptor.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0014-5793
|
pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
19
|
pubmed:volume |
211
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
69-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3803588-Adipose Tissue,
pubmed-meshheading:3803588-Animals,
pubmed-meshheading:3803588-Autoantibodies,
pubmed-meshheading:3803588-Cell Membrane,
pubmed-meshheading:3803588-Chorionic Gonadotropin,
pubmed-meshheading:3803588-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:3803588-Graves Disease,
pubmed-meshheading:3803588-Guinea Pigs,
pubmed-meshheading:3803588-Humans,
pubmed-meshheading:3803588-Male,
pubmed-meshheading:3803588-Receptors, Thyrotropin,
pubmed-meshheading:3803588-Thyrotropin
|
pubmed:year |
1987
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pubmed:articleTitle |
Demonstration by immunoblotting of heterogeneity in the autoantibody response directed against fat cells in Graves' disease.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|