Linked Life Data

3798960

Source:http://linkedlifedata.com/resource/pubmed/id/3798960

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1987-2-11
pubmed:abstractText
The acetylator phenotype was determined for 142 Nigerian adults by administering sulphamethazine (40 mg/kg body wt) and analysing six hour urines for free and acetylated drug. Of these 142 subjects, 21 (14.8%) had no red cell glucose 6-phosphate dehydrogenase activity, 35 (24.6%) had partial activity and 86 (60.56%) had normal activity. The percentage of slow acetylators among the three groups was 38.1%, 40% and 40.7% respectively. The differences between the three groups were not statistically significant. However, individuals with no red cell glucose 6-phosphate dehydrogenase activity and who are also slow acetylators may be more sensitive to the effects of drugs like sulphamethazine, dapsone and isoniazid.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0049-8254
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1129-32
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Acetylator phenotype among individuals with glucose 6-phosphate dehydrogenase variants.
pubmed:publicationType
Journal Article