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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1987-2-19
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pubmed:abstractText |
Endoscopic biopsies were taken from the oxyntic mucosa in patients with duodenal ulcer (DU) before and after 4 weeks of treatment with omeprazole. Biopsies were also obtained from Zollinger-Ellison (ZE) patients before and during treatment with omeprazole; these patients had previously failed to respond to other therapies aiming at reducing gastric acid secretion. Healthy volunteers served as controls. Light-microscopic studies of biopsy sections revealed superficial gastritis in most of the patients. Endocrine cell volume density (that is, the percentage of mucosal volume occupied by endocrine cells) was 0.3% in the DU patients and 0.7% in the ZE patients before omeprazole treatment. No significant change occurred during omeprazole treatment, which in the ZE patients continued for up to 21 months. In the controls, 0.3% of the mucosal volume was occupied by endocrine cells. Parietal cell volume density was about 15% in both the DU patients and in the controls; in the ZE patients, slightly but not significantly higher values were recorded. No significant change was observed during omeprazole treatment.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0012-2823
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
35 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3792669-Adult,
pubmed-meshheading:3792669-Biopsy,
pubmed-meshheading:3792669-Duodenal Ulcer,
pubmed-meshheading:3792669-Female,
pubmed-meshheading:3792669-Gastric Mucosa,
pubmed-meshheading:3792669-Humans,
pubmed-meshheading:3792669-Male,
pubmed-meshheading:3792669-Middle Aged,
pubmed-meshheading:3792669-Omeprazole,
pubmed-meshheading:3792669-Parietal Cells, Gastric,
pubmed-meshheading:3792669-Zollinger-Ellison Syndrome
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pubmed:year |
1986
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pubmed:articleTitle |
Oxyntic mucosa histology in omeprazole-treated patients suffering from duodenal ulcer or Zollinger-Ellison syndrome.
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pubmed:publicationType |
Journal Article
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