Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1979-9-25
pubmed:abstractText
We have shown recently (Alarcón-Segovia, Ruíz-Argüelles & Fishbein, 1978) that an IgG anti-RNP antibody obtained from a patient with mixed connective tissue disease (MCTD) can penetrate viable mononuclear cells (MNC) from normal donors via their Fc receptors. Live MNC from twelve MCTD patients incubated with goat anti-Ig antibody had intranuclear antibody with a speckled pattern in a mean of 5.5% of all MNC and 57.3% of all Fc receptor-bearing MNC. We found intranuclear immunoglobulins in all twelve patients with MCTD which were present only in cells with Fc receptors. Only three out of twenty-one patients with systemic lupus erythematosus (SLE) were found to have intranuclear antibody in a mean of 17.2% of their Fc receptor-bearing cells. Further experiments with MNC from SLE patients revealed a partial blocking of penetration of antibody via Fc receptors. MNC from ten scleroderma, ten rheumatoid arthritis patients and eleven normal controls did not have intranuclear immunoglobulin. In vivo penetration of autoantibodies into Fc receptor-bearing cells in MCTD, and probably in SLE as well, may represent an important pathogenetic mechanism.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-1084016, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-1095019, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-13372565, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-14171573, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-14210996, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-172224, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-180179, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-303151, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-304591, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-332183, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-4097823, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-4108866, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-4113562, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-4143707, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-4158434, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-4164259, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-4541574, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-4621694, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-4992992, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-50451, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-562379, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-6022520, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-67824, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-781134, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-886184, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-950463, http://linkedlifedata.com/resource/pubmed/commentcorrection/378481-950635
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
364-75
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Antibody penetration into living cells. I. Intranuclear immunoglobulin in peripheral blood mononuclear cells in mixed connective tissue disease and systemic lupus erythematosus.
pubmed:publicationType
Journal Article, In Vitro