Linked Life Data

3780884

Source:http://linkedlifedata.com/resource/pubmed/id/3780884

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-1-14
pubmed:abstractText
Retinal detachments are frequently accompanied by retinal pigment epithelial cell and glial cell proliferation. This may be important in the pathogenesis of proliferative vitreoretinopathy and may also play a role in the failure of some eyes to regain visual function despite anatomically successful retinal reattachment surgery. In this study, we demonstrate that a retina-derived substance or substances stimulates the proliferation of retinal pigment epithelial cells (250% above control) and astrocytes (150% above control) in vitro. The stimulation of proliferation occurs in the absence of serum, but is accentuated by serum. There is some degree of target-cell specificity as there is no stimulation of smooth-muscle-cell proliferation. Morphologic changes induced in the proliferating cell types as well as preliminary characterization suggest that one or more of the previously described eye-derived growth factors may be involved.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0014-4835
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
449-57
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
A retina-derived stimulator(s) of retinal pigment epithelial cell and astrocyte proliferation.
pubmed:publicationType
Journal Article