Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
|
pubmed:dateCreated |
1986-12-18
|
pubmed:abstractText |
Development continues for a safe and effective hemoglobin solution to be used as a temporary red cell substitute. Our own efforts have progressed from the unmodified tetramer, to the pyridoxylated tetramer, to our current product--polymerized, pyridoxylated hemoglobin (Poly SFH-P). We recently completed two studies to evaluate the efficacy of Poly SFH-P. The results document that Poly SFH-P supports life in the absence of red cells while maintaining baseline hemodynamics and O2 consumption. In addition, Poly SFH-P achieves a near-normal plasma [Hb], and has a longer intravascular persistence than any unpolymerized product. Poly SFH-P thus is an improved red cell substitute for use in the clinical setting.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0196-0644
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
15
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1416-9
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3777613-Anemia,
pubmed-meshheading:3777613-Animals,
pubmed-meshheading:3777613-Blood Substitutes,
pubmed-meshheading:3777613-Drug Evaluation, Preclinical,
pubmed-meshheading:3777613-Hematocrit,
pubmed-meshheading:3777613-Hemodynamics,
pubmed-meshheading:3777613-Hemoglobins,
pubmed-meshheading:3777613-Humans,
pubmed-meshheading:3777613-Oxygen Consumption,
pubmed-meshheading:3777613-Papio,
pubmed-meshheading:3777613-Pyridoxal Phosphate
|
pubmed:year |
1986
|
pubmed:articleTitle |
The development of polymerized pyridoxylated hemoglobin solution as a red cell substitute.
|
pubmed:publicationType |
Journal Article
|