Linked Life Data

3772394

Source:http://linkedlifedata.com/resource/pubmed/id/3772394

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-12-4
pubmed:abstractText
IAP, a type of alpha 1-acid glycoprotein, is mainly produced by macrophages when stimulated in the presence of circulating immune complexes or some inflammatory substances. We assayed the serum levels of IAP by a single radial immunodiffusion method. The normal level of IAP is below 500 micrograms/ml (385 +/- 73). In multiple sclerosis patients, however, IAP increased during exacerbation (630 +/- 191) and decreased during the inactive stage (433 +/- 170). Eighty-five percent of patients with neuro-Behcet's disease also had high levels of IAP, correlating well with disease activity. In some patients with Guillain-Barré syndrome or Miller Fisher syndrome, IAP increased during the acute phase. In patients with herpes simplex encephalitis, IAP levels remained abnormally high for more than 60 days after onset. The mean value of IAP in patients with amyotrophic lateral sclerosis did not differ from that of normal controls. An increase in IAP in the serum of patients seems to reflect the activity of an inflammatory or immunopathological process.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-510X
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
353-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Significant increase in immunosuppressive acidic protein (IAP) in serum of patients with multiple sclerosis and other inflammatory neurological disorders.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't