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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1986-11-10
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pubmed:abstractText |
Six monoclonal antibodies (MAbs) against the haemagglutinin-neuraminidase (HN) protein and three against the fusion (F) protein of mumps virus were obtained. Anti-HN MAbs were classified into three antigen-specific groups in competitive binding assays. All of the anti-HN MAbs showed virus-neutralizing and haemolysis-inhibiting activities and inhibited fusion from without (FFWO). Three of them inhibited fusion from within (FFWI) and the cell-to-cell spread of infection. The most effective MAb in inhibiting FFWI possessed neuraminidase-inhibiting activity and little haemagglutination-inhibiting activity. All anti-F MAbs inhibited virus-induced haemolysis but none of them inhibited FFWO, FFWI or the cell-to-cell spread of infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1317
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67 ( Pt 10)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2259-65
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3760826-Animals,
pubmed-meshheading:3760826-Antibodies, Monoclonal,
pubmed-meshheading:3760826-Antibodies, Viral,
pubmed-meshheading:3760826-Cell Fusion,
pubmed-meshheading:3760826-Cell Line,
pubmed-meshheading:3760826-Cytopathogenic Effect, Viral,
pubmed-meshheading:3760826-HN Protein,
pubmed-meshheading:3760826-Mumps virus,
pubmed-meshheading:3760826-Viral Envelope Proteins,
pubmed-meshheading:3760826-Viral Fusion Proteins
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pubmed:year |
1986
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pubmed:articleTitle |
Monoclonal antibodies against the glycoproteins of mumps virus: fusion inhibition by anti-HN monoclonal antibody.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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