Linked Life Data

3760403

Source:http://linkedlifedata.com/resource/pubmed/id/3760403

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3 Pt 1
pubmed:dateCreated
1986-11-4
pubmed:abstractText
Sulfiting agents have been reported to cause anaphylaxis, asthma, urticaria/angioedema, seizure, nausea, abdominal pain and diarrhea, and death. There is no consensus regarding the pathogenesis of these reactions. The possible role of IgE-mediated mechanism has been debated. To clarify the pathogenesis of these reactions, we studied 53 patients with a variety of symptoms related to either restaurant meals or alcoholic beverages. Food allergy was excluded as a cause of their symptoms by means of skin testing and elimination diet. Symptoms included urticaria/angioedema (32), asthma (nine), headache (eight), rhinoconjunctivitis (two), and abdominal pain (one), and one patient with anaphylaxis. Twenty normal control subjects were studied as well. Prick and intradermal skin testing with potassium metabisulfite (K2S2O5, 1 mg/ml) were carried out on all subjects. Single-blind oral provocative challenge tests were conducted with placebo (lactose) and with 1, 5, 10, 25, and 50 mg of K2S2O5 in all nine subjects with asthma, nine patients with urticaria/angioedema (excluding one subject with severe coronary insufficiency and positive skin testing to 1 mg of K2S2O5), four subjects with headache, one subject with rhinoconjunctivitis, and one patient with anaphylaxis. Pulmonary function tests (FEV1 and FVC) were measured in all subjects with asthma. Five patients had positive skin tests. One subject with asthma had a positive prick test. Four positive intradermal tests occurred (two subjects with asthma, one subject with urticaria/angioedema, and one subject with anaphylaxis). Single-blind oral provocative challenge testing was positive in the subject with anaphylaxis, as was intradermal skin testing, and also in three subjects with asthma, two of whom had positive skin testing.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0091-6749
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
443-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Positive skin tests and Prausnitz-Küstner reactions in metabisulfite-sensitive subjects.
pubmed:publicationType
Journal Article, Clinical Trial, Case Reports, Controlled Clinical Trial, Research Support, Non-U.S. Gov't