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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
19
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pubmed:dateCreated |
1979-9-27
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pubmed:abstractText |
It was shown that recent Swedish clinical isolates of anaerobic bacteria are susceptible to many antibiotics by the agar dilution method with the exception of the Bacteroides group versus beta-lactam antibiotics or tetracyclines. Strains of B. fragilis were inhibited by 4--greater than 128 micrograms benzylpenicillin or cephalothin/ml, 1.0--64 micrograms cefoxitin/ml, 0.064--2 micrograms clindamycin or metronidazole/ml, 2--8 micrograms chloramphenicol/ml, 2--16 micrograms fusidic acid/ml and 0.032--32 micrograms doxycycline/ml. Resistance to beta-lactam antibiotics was partly due to the production of beta-lactamase. Growth of beta-lactamase producing strains in the presence of enzyme inhibitors such as clavulanic acid or CP-45899 together with cephaloridine lowered the MIC's manyfold. Cefoxitin with relative resistance to beta-lactamases inhibited the majority of the strains at 8 micrograms/ml. Cefoxitin-resistant strains (MIC greater than or equal to 16 micrograms/ml) were also resistant to the new cephalosporins BL-S786 and HR-756 as well as to the new cefamycins A, B, CL619-183, CS-1170 and Sq-14359 and to thienamycin. Cefamycin CL619-183, only showed a slightly higher in vitro activity than cefoxitin. Resistance to the cefamycins could not be correlated to the production of beta-lactamases.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0300-8878
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17-25
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:37593-Anti-Bacterial Agents,
pubmed-meshheading:37593-Bacteroides fragilis,
pubmed-meshheading:37593-Cephaloridine,
pubmed-meshheading:37593-Clostridium,
pubmed-meshheading:37593-Drug Resistance, Microbial,
pubmed-meshheading:37593-Fusobacterium,
pubmed-meshheading:37593-Gram-Negative Anaerobic Bacteria,
pubmed-meshheading:37593-Metronidazole,
pubmed-meshheading:37593-Microbial Sensitivity Tests,
pubmed-meshheading:37593-Prevotella melaninogenica,
pubmed-meshheading:37593-beta-Lactamases
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pubmed:year |
1979
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pubmed:articleTitle |
Antibiotic susceptibility of anaerobic bacteria with special reference to Bacteroides fragilis.
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pubmed:publicationType |
Journal Article
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