Linked Life Data

3757963

Source:http://linkedlifedata.com/resource/pubmed/id/3757963

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-10-30
pubmed:abstractText
Rabbits were exposed to aerosols of hexavalent (Na2CrO4) and trivalent chromium (Cr(NO3)3) at concentrations of 0.9 and 0.6 mg/m3 of chromium respectively for 4-6 weeks (5 days/week and 6 hr/day). Three of eight rabbits exposed to Cr(VI) and three of eight rabbits exposed to Cr(III) showed nodular accumulations of alveolar macrophages, similar to the lesions observed in previous experiments after exposure to Ni2+, Cd2+, or metallic nickel. Macrophages from rabbits exposed to Cr(III) usually contained round dark inclusions, large lysosomes, and laminated inclusions similar to the lamellar bodies in the type II cells, and most macrophages from rabbits exposed to Cr(VI) showed enlarged lysosomes. However, the total amount of phospholipids and the volume density of type II cells did not differ significantly between exposed rabbits and controls. Our findings indicate that the macrophages are directly affected by chromium. The accumulation of laminated structures in the alveolar macrophages after Cr(III) exposure might be due to an impaired catabolism of surfactant.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0013-9351
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
110-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Rabbit lung after inhalation of hexa- and trivalent chromium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't