Linked Life Data

3745878

Source:http://linkedlifedata.com/resource/pubmed/id/3745878

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-10-22
pubmed:abstractText
The metabolism of ethanol can result in depletion of reduced glutathione (GSH) via adduct formation and oxidation to GSSG. In this study, the glutathione concentration in liver tissue of chronic alcoholic patients (n = 20) was measured using a specific chromatographic method. The results are compared to values obtained from a group of selected controls (n = 10), and correlated to liver histology and blood biochemistry. All of the alcoholics had markedly lower hepatic GSH concentrations than the control group (medians = 2.17 vs 3.88 mumol/g liver, respectively). No significant differences in liver GSH were found among alcoholic subgroups who had slightly altered or normal histology and/or blood tests vs those with advanced pathology. A decrease in hepatic GSH concentration seems to be a consistent characteristic of chronic alcohol abuse which occurs even in the absence of evident liver damage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0168-8278
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Decreased hepatic glutathione in chronic alcoholic patients.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't