Linked Life Data

3743420

Source:http://linkedlifedata.com/resource/pubmed/id/3743420

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7-8
pubmed:dateCreated
1986-10-10
pubmed:abstractText
Twelve elderly institutionalized patients (mean age of 81 years) received intramuscular injections of tobramycin for infections at regular dosage intervals. The subjects had stable renal function but had limited mobility. Periodic blood specimens were collected for eight hours and analyzed for tobramycin by an immunofluorescence technique. The procedure was repeated in each patient one day later to detect day-to-day variability in the absorption kinetics. The absorption of tobramycin occurred primarily within two hours, although peak concentrations in some patients were indicative of a sustained plateau and exhibited intrapatient variability from one dose to the next. The time to peak and slowly declining concentrations suggest that the absorption process is extended in this population as compared to younger adults. Our data suggest that peak tobramycin concentrations following intramuscular injections to geriatric patients may be slightly delayed, though the extent of absorption appears to be consistent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0012-6578
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
611-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Intramuscular tobramycin pharmacokinetics in geriatric patients.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't