Linked Life Data

3738217

Source:http://linkedlifedata.com/resource/pubmed/id/3738217

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-9-25
pubmed:abstractText
The mean time between contractions of lymphangions of mesenteric lymph collectors in anaesthetised guinea pigs was 7.6 +/- 6.7s. The administration of saline had no significant effect on contraction times, nor did 50 mg/kg of calcium dobesilate in saline as a vehicle. However, at dose levels of 100 mg/kg and 200 mg/kg using saline as a vehicle the time between contractions significantly (P less than 0.001) increased to 11.4 +/- 14.8s and 12.9 +/- 23.3s, respectively. While neither the saline vehicle alone nor calcium dobesilate at any dose level influenced maximal collector diameters significantly, all dose levels of calcium dobesilate significantly (0.05 greater than P greater than 0.01) reduced minimal lumenal diameters to 30% of their maximum. The time that the lymphangion spends at its minimal diameter is an indication of the intensity of contraction. Saline alone had no significant effect, but calcium dobesilate at 50 mg/kg and 100 mg/kg significantly (0.05 greater than P greater than 0.01) increased this time from 0.9 +/- 1.2s to 1.9 +/- 1.9s and 2.0 +/- 1.6s, respectively. At 200 mg/kg of calcium dobesilate, there was a very significant increase (P less than 0.001) in minimal diameter times to 2.7 +/- 1.5s.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9130
pubmed:author
pubmed:issnType
Print
pubmed:volume
186
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-72
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Effect of calcium dobesilate on the functional capabilities of mesenteric lymphatics in the guinea pig.
pubmed:publicationType
Journal Article