Linked Life Data

3729164

Source:http://linkedlifedata.com/resource/pubmed/id/3729164

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-8-8
pubmed:abstractText
Exercise causes bronchoconstriction in asthmatic subjects, which is usually followed by a refractory period during which exercise of the same intensity will cause less bronchoconstriction. This study examined the role of contractile prostaglandins in the initial bronchoconstriction after exercise and the role of inhibitory prostaglandins in the refractoriness after exercise. Subjects were pretreated with indomethacin, 50 mg twice daily, on 1 occasion or placebo on 2 occasions for 3 days. This was followed by 2 exercise challenges on a bicycle ergometer at least 30 min apart. Indomethacin did not alter the initial bronchoconstriction after exercise. The maximal fall in FEV1 after the first exercise challenge after placebo was 0.67 +/- 0.17 L and 0.68 +/- 0.17 L, and after indomethacin it was 0.67 +/- 0.12 L. Indomethacin, however, did prevent refractoriness after exercise. The maximal fall in FEV1 after the second exercise challenge after placebo was 0.31 +/- 0.06 L and 0.36 +/- 0.12 L, and after indomethacin it was 0.64 +/- 0.12 L. These results indicate that indomethacin pretreatment does not alter bronchoconstriction after exercise, and they also indicate that indomethacin pretreatment prevents refractoriness after exercise in asthmatic subjects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-72
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
The effect of indomethacin on exercise-induced bronchoconstriction and refractoriness after exercise.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial, Research Support, Non-U.S. Gov't