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pubmed-article:3725199pubmed:abstractTextThe effects of gamma-aminobutyric acid transaminase (GABA-T) inhibitors on rat endothelial GABA-T activity has been studied utilizing a modified tetrazolium salt histochemical technique. Blue-diformazan staining of cerebrovascular and parenchymal sites of GABA catabolism in normal brain was almost completely prevented in unfixed frozen brain sections from rats subjected to 'in vivo' GABA-T inhibition using aminooxyacetic acid or gabaculine. These results provide histochemical evidence for the efficacy of using systemically administered GABA-T inhibitors to inhibit endothelial GABA-T activity.lld:pubmed
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pubmed-article:3725199pubmed:articleTitleCerebral endothelial GABA-T activity: effects of in vivo GABA-T inhibition.lld:pubmed
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