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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
1
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pubmed:dateCreated |
1986-8-13
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pubmed:abstractText |
The effects of gamma-aminobutyric acid transaminase (GABA-T) inhibitors on rat endothelial GABA-T activity has been studied utilizing a modified tetrazolium salt histochemical technique. Blue-diformazan staining of cerebrovascular and parenchymal sites of GABA catabolism in normal brain was almost completely prevented in unfixed frozen brain sections from rats subjected to 'in vivo' GABA-T inhibition using aminooxyacetic acid or gabaculine. These results provide histochemical evidence for the efficacy of using systemically administered GABA-T inhibitors to inhibit endothelial GABA-T activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0304-3940
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
48-52
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3725199-4-Aminobutyrate Transaminase,
pubmed-meshheading:3725199-Acetic Acids,
pubmed-meshheading:3725199-Aminooxyacetic Acid,
pubmed-meshheading:3725199-Animals,
pubmed-meshheading:3725199-Blood Vessels,
pubmed-meshheading:3725199-Blood-Brain Barrier,
pubmed-meshheading:3725199-Brain,
pubmed-meshheading:3725199-Cyclohexanecarboxylic Acids,
pubmed-meshheading:3725199-Endothelium,
pubmed-meshheading:3725199-Histocytochemistry,
pubmed-meshheading:3725199-Male,
pubmed-meshheading:3725199-Rats,
pubmed-meshheading:3725199-Rats, Inbred Strains
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pubmed:year |
1986
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pubmed:articleTitle |
Cerebral endothelial GABA-T activity: effects of in vivo GABA-T inhibition.
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pubmed:publicationType |
Journal Article
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