Linked Life Data

3720691

Source:http://linkedlifedata.com/resource/pubmed/id/3720691

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-8-20
pubmed:abstractText
The effects of lysophosphatidylcholine (lysoPC) on airway and capillary permeability in the isolated perfused rat lung were investigated. We determined the influence of lysoPC on the passage of different-sized (326-722 dalton) polyethylene glycols (PEGs), both from the airways to the pulmonary circulation and from the pulmonary circulation into the lung. We found that 1 mM lysoPC increased the overall passage of PEGs from the airways to the pulmonary circulation, and that 80 microM lysoPC increased the overall passage from the circulation into the lung. In both cases, the passage of the larger (502-722 dalton) PEGs increased more than the passage of the smaller (326-458 dalton) PEGs. We also found that the presence of lysoPC in the circulation increased the pulmonary arterial pressure, whereas deposition of lysoPC in the trachea did not. The pressure increase was blocked by indomethacine, BW755C, and quinacrine, inhibitors of arachidonic acid metabolism. These findings suggest that higher concentrations of lysoPC increase the airway permeability to larger molecules, and that lower concentrations of lysoPC increase the capillary permeability. The increase in capillary permeability may be due to a rise in capillary pressure mediated by arachidonic acid metabolites. The possibility that formation and accumulation of lysoPC is of importance for mediating inflammatory reactions in the lung is inferred.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0190-2148
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Lysophosphatidylcholine increases airway and capillary permeability in the isolated perfused rat lung.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't