Linked Life Data

3715916

Source:http://linkedlifedata.com/resource/pubmed/id/3715916

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-6-27
pubmed:abstractText
Neurotoxic esterase (NTE) is a protein which is hypothesized to be the site where certain organophosphorus compounds act to produce delayed-onset neurotoxicity. Adult white Leghorn hens (Gallus domesticus) were injected subcutaneously (0.5 mg/kg and 2.0 mg/kg) with diisopropyl phosphorofluoridate (DFP). Control and DFP-treated hens were killed 24 h after treatment and their brains sectioned into telencephalic, cerebellar, diencephalic, mesencephalic, metencephalic tegmentum, and myelencephalic portions. NTE activity was highest in the telencephalon and cerebellum, and brainstem activity progressively decreased moving caudally with the myelencephalon approaching reported spinal cord levels. Percent inhibition of NTE by DFP (0.5 mg/kg and 2.0 mg/kg) did not differ among brain regions or whole brain. The IC50's for DFP were not significantly different either among brain regions or whole brain. The results suggest that nervous system regions with higher NTE levels are protected from delayed neuropathy by virtue of overabundant NTE activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0378-4274
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-56
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Distribution of neurotoxic esterase activity in the brain of control and diisopropyl phosphorofluoridate-treated hens: in vivo and in vitro exposure.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't